Simulators for planning clinical trials

  On the importance of control group: two-arms clinical trial with non-especific effects (normallity distributed outcome)

  Two-arms parallel clinical trial with binary outcome

  Multi-arm clinical trial with normally distributed outcome (one-way ANOVA)

  Multicentric (blocks) design for evaluating multi-arm treatments

  Longitudinal trial comparing treatments and repeated measurements for each subject. Include subject variability (mixed model)

  Longitudinal trial comparing two treatments and repeated measurements for each subject (continous time): Using splines

  Repeated Latin squares designs: mixed models with control for two random factors

  Nested designs

  Analysis of repeated latin squares with repeated measures

This is a situation that corresponds to a common design in animal nutrition. Each latin square has different animals and periods of observation, and each animal is measured in different days.